Search results for "model [interaction]"
showing 10 items of 1495 documents
Effects of COVID-19 on Business Models in Romania and the Netherlands, A Digitalization Perspective
2020
Abstract The research objective is to study how Romanian and Dutch organizations’ business models have changed under COVID-19 conditions. The role of digitalization in adapting business models and business practices is studied. The theoretical background reviews literature about business models and their dimensions. Literature review investigated digitalization in Romanian and Dutch organizations. Research questions were: To what extent do Romanian and Dutch organizations use: • more digital methods in their offer to their clients now than before the crisis? • more digital methods in their business processes now than before the crisis? • more digital methods in communicating with their clie…
β-Catenin Contributes to Lung Tumor Development Induced by EGFR Mutations
2014
Abstract The discovery of somatic mutations in EGFR and development of EGFR tyrosine kinase inhibitors (TKI) have revolutionized treatment for lung cancer. However, resistance to TKIs emerges in almost all patients and currently no effective treatment is available. Here, we show that β-catenin is essential for development of EGFR-mutated lung cancers. β-Catenin was upregulated and activated in EGFR-mutated cells. Mutant EGFR preferentially bound to and tyrosine phosphorylated β-catenin, leading to an increase in β-catenin–mediated transactivation, particularly in cells harboring the gefitinib/erlotinib-resistant gatekeeper EGFR-T790M mutation. Pharmacologic inhibition of β-catenin suppresse…
Modelling biological nitrogen and phosphorus removal with soluble microbial products (SMP) production-degradation processes
2011
Over the last two decades, Membrane Bioreactors (MBR) are increasingly used for wastewater treatment. Mathematical modelling of MBR systems has played a key role in order to better explain the effect of their peculiarities. Indeed, several MBR models have been presented in literature in order to improve the knowledge on MBR systems: biological models, hybrid models which include soluble microbial product (SMP) modelling, physical models able to describe the membrane fouling and integrated models which couple the hybrid models with the physical ones. However, among the existing MBR models only few integrated models have been developed which take into account the existing relationship between…
Existence of fixed points for the sum of two operators
2010
The purpose of this paper is to study the existence of fixed points for the sum of two nonlinear operators in the framework of real Banach spaces. Later on, we give some examples of applications of this type of results (© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
Learning multiresolution schemes for compression of images
2007
We introduce a new type of multiresolution based on the Harten's framework using learning theory. This changes the point of view of the classical multiresolution analysis and it transforms an approximation problem in a learning problem opening great possibilities. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
Outlier recognition in crystal-structure least-squares modelling by diagnostic techniques based on leverage analysis.
2005
The identification of the actual outliers in a least-squares crystal-structure model refinement and their subsequent elimination from the data set is a non-trivial task that has to be carried out carefully when a high level of accuracy of the estimates is required. One of the most suitable tools for detecting the influence of each data entry on the regression is the identification of ;leverage points'. On the other hand, the recognition of the actual statistical outliers is effectively possible by using some diagnostics as a function of the leverage, such as Cook's distance, DFFITS and FVARATIO. The evaluation of these estimators makes it possible to achieve a reliable identification of the…
Cholesterol Starvation and Hypoxia Activate the FVII Gene via the SREBP1-GILZ Pathway in Ovarian Cancer Cells to Produce Procoagulant Microvesicles
2019
AbstractInteraction between the transcription factors, hypoxia-inducible factor (HIF1α and HIF2α) and Sp1, mediates hypoxia-driven expression of FVII gene encoding coagulation factor VII (fVII) in ovarian clear cell carcinoma (CCC) cells. This mechanism is synergistically enhanced in response to serum starvation, a condition possibly associated with tumor hypoxia. This transcriptional response potentially results in venous thromboembolism, a common complication in cancer patients by producing procoagulant extracellular vesicles (EVs). However, which deficient serum factors are responsible for this characteristic transcriptional mechanism is unknown. Here, we report that cholesterol deficien…
Surfaces of minimal degree of tame representation type and mutations of Cohen–Macaulay modules
2017
We provide two examples of smooth projective surfaces of tame CM type, by showing that any parameter space of isomorphism classes of indecomposable ACM bundles with fixed rank and determinant on a rational quartic scroll in projective 5-space is either a single point or a projective line. For surfaces of minimal degree and wild CM type, we classify rigid Ulrich bundles as Fibonacci extensions. For the rational normal scrolls S(2,3) and S(3,3), a complete classification of rigid ACM bundles is given in terms of the action of the braid group in three strands.
Conical upper density theorems and porosity of measures
2008
Abstract We study how measures with finite lower density are distributed around ( n − m ) -planes in small balls in R n . We also discuss relations between conical upper density theorems and porosity. Our results may be applied to a large collection of Hausdorff and packing type measures.
Relationships between sodium mobility, in-mouth salt and aroma release, and flavour perception : application to model cheeses
2012
The aim of this work is to understand the effects of changes in the composition of model cheeses on mobility, release and perception of flavor molecules (salt, aroma compounds). Six flavoured model cheeses were formulated (3 lipid/protein (L/P) ratios and 2 salt contents). The microstructure and the rheological properties of the model cheeses were characterized respectively by confocal microscopy and by uniaxial compression test. The mobility of sodium ions was analyzed by 23Na NMR. The kinetics of sodium release was followed in water and then in saliva during consumption of the model cheeses. The retronasal release of aroma compounds was followed by nose-space APCI-MS, simultaneously with …